More information will be provided after intial double-blind application process.

Kühbacher A, Birch M, Oliver JD, Gsaller F. Anti-Aspergillus activities of olorofim at sub-MIC levels during early-stage growth. Microbiol Spectr. 2024 Mar 5;12(3):e0330423. doi: 10.1128/spectrum.03304-23

Kühbacher A, Merschak P, Haas H, Liebl M, Müller C, Gsaller F. The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0091823. doi: 10.1128/aac.00918-23.

Sastré-Velásquez LE, Dallemulle A, Kühbacher A, Baldin C, Alcazar-Fuoli L, Niedrig A, Müller C, Gsaller F. The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment. PLoS Pathog. 2022 Dec 27;18(12):e1011066. doi: 10.1371/journal.ppat.1011066.

Kühbacher A, Peiffer M, Hortschansky P, Merschak P, Bromley MJ, Haas H, Brakhage AA, Gsaller F. Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus. Microbiol Spectr. 2022 Jun 29;10(3):e0120922. doi: 10.1128/spectrum.01209-22.

Baldin C, Kühbacher A, Merschak P, Wagener J, Gsaller F. Modular Inducible Multigene Expression System for Filamentous Fungi. Microbiol Spectr. 2022 Dec 21;10(6):e0367022. doi: 10.1128/spectrum.03670-22.

Baldin C, Kühbacher A, Merschak P, Sastré-Velásquez LE, Abt B, Dietl AM, Haas H, Gsaller F. Inducible Selectable Marker Genes to Improve Aspergillus fumigatus Genetic Manipulation. J Fungi (Basel). 2021 Jun 24;7(7):506. doi: 10.3390/jof7070506.

Birštonas L, Dallemulle A, López-Berges MS, Jacobsen ID, Offterdinger M, Abt B, Straßburger M, Bauer I, Schmidt O, Sarg B, Lindner H, Haas H, Gsaller F. Multiplex Genetic Engineering Exploiting Pyrimidine Salvage Pathway-Based Endogenous Counterselectable Markers. mBio. 2020 Apr 7;11(2):e00230-20. doi: 10.1128/mBio.00230-20.

Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P. The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res. 2020 Apr 17;48(7):3567-3590. doi: 10.1093/nar/gkaa109.

Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ. The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1.

Gsaller F, Furukawa T, Carr PD, Rash B, Jöchl C, Bertuzzi M, Bignell EM, Bromley MJ. Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2018 May 25;62(6):e02593-17. doi: 10.1128/AAC.02593-17.