Research Questions/Hypotheses
(i) Are there any correlations of azole antifungals and infections post-transplant / antifungal resistances and levels of immunosuppressive drugs? (ii) Is there any azole-content in the ‘native’ donor and donor organ respectively? (iii) Is there any pre-existing azole content of the potential organ transplant recipient? (iv) Does the pre-existing azole content of the deceased organ donor correlate with donor demographics and laboratory parameters? (v) Does the pre-existing azole content of the organ recipient correlate with recipient demographics and laboratory parameters? (vi) Does the pre-existing azole content of donor organ and/or recipient interfere with the outcome (graft and patient survival) after solid organ transplantation?
Approach/Methods
The PhD student will be working on a clinical trial investigating the pre-existing azole burden in deceased donor organs and organ transplant recipients (liver and kidney) and its correlation with the clinical outcome comprising graft and patient survival, invasive fungal infections, period of treatment, interaction with immunosuppressive drugs.
